Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis.
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ABSTRACT: Purpose
The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others.Design
This investigation is a systematic review and meta-analysis.Methods
All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression.Results
Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes.Conclusions
Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.
SUBMITTER: Van Swol JM
PROVIDER: S-EPMC9672185 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis.
Van Swol Joshua M JM Myers Walter K WK Beall Jonathan A JA Atteya Miriam M MM Blice Jeffrey P JP
Journal of ophthalmic inflammation and infection 20221118 1
<h4>Purpose</h4>The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others.<h4>Design</h4>This investigation is a systematic review and meta-analysis.<h4>Methods</h4>All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression.<h4>Results</h4>Time course ...[more]
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