Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.

ABSTRACT:

Objective

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) is essential for the formation of fully functional multinucleated osteoclasts. DC-STAMP deficient mice, under physiological conditions, exhibit osteopetrosis and develop systemic autoimmunity with age. However, the function of DC-STAMP in inflammation is currently unknown. We examined whether genetic ablation of DC-STAMP attenuates synovitis and bone erosion in TNF transgenic (Tg) and K/BxN serum-induced murine rheumatoid arthritis.

Methods

We evaluated arthritis onset in Tg(hTNF) mice lacking DC-STAMP and 50:50 chimeric mice by visual examination, measurement of ankle width, micro-CT-scan analysis and quantitation of the area occupied by osteoclasts in bone sections. To further investigate the cellular and m

SUBMITTER: Garcia-Hernandez ML 

PROVIDER: S-EPMC9677122 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature