Neurofilament light-associated connectivity in young-adult Huntington's disease is related to neuronal genes.

ABSTRACT: Upregulation of functional network connectivity in the presence of structural degeneration is seen in the premanifest stages of Huntington's disease (preHD) 10-15 years from clinical diagnosis. However, whether widespread network connectivity changes are seen in gene carriers much further from onset has yet to be explored. We characterized functional network connectivity throughout the brain and related it to a measure of disease pathology burden (CSF neurofilament light, NfL) and measures of structural connectivity in asymptomatic gene carriers, on average 24 years from onset. We related these measurements to estimates of cortical and subcortical gene expression. We found no overall differences in functional (or structural) connectivity anywhere in the brain comparing control and preHD pa

SUBMITTER: McColgan P 

PROVIDER: S-EPMC9679168 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature