A single birth dose of Hepatitis B vaccine induces polyfunctional CD4⁺ T helper cells.

ABSTRACT: A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4⁺ T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4⁺ T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154⁺IL-2⁺TNFα⁺

SUBMITTER: Strandmark J 

PROVIDER: S-EPMC9681035 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature