Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
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ABSTRACT:
SUBMITTER: Zhang JY
PROVIDER: S-EPMC9705541 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Low-dose IL-2 reduces IL-21<sup>+</sup> T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Zhang Jia-Yuan JY Hamey Fiona F Trzupek Dominik D Mickunas Marius M Lee Mercede M Godfrey Leila L Yang Jennie H M JHM Pekalski Marcin L ML Kennet Jane J Waldron-Lynch Frank F Evans Mark L ML Tree Timothy I M TIM Wicker Linda S LS Todd John A JA Ferreira Ricardo C RC
Nature communications 20221128 1
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples. Our results confirm that iLD-IL-2 selectively expands thymic-derived FOXP3<sup>+</sup>HELIOS<sup>+</sup> regulatory T cells and ...[more]
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