Serum uromodulin in dogs with chronic kidney disease.

ABSTRACT:

Background

Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs.

Objective

To evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs.

Animals

Forty-nine dogs with CKD (International Renal Interest Society [IRIS] Stage 1, n = 23; Stage 2, n = 20; Stage 3-4, n = 6) and 25 healthy controls.

Methods

Prospective, observational study. Serum uromodulin concentration was measured using a canine-specific enzyme-linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed.

Results

Serum uromodulin concentrations were significantly lower in the CKD group than in

SUBMITTER: Seo D 

PROVIDER: S-EPMC9708433 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature