Dataset Information

Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.

ABSTRACT:

Background

Clinicians and patients want to know the benefits and harms of outpatient treatment options for SARS-CoV-2 infection.

Purpose

To assess the benefits and harms of 12 different COVID-19 treatments in the outpatient setting.

Data sources

Epistemonikos COVID-19 L·OVE Platform, searched on 4 April 2022.

Study selection

Two reviewers independently screened abstracts and full texts against a priori-defined criteria. Randomized controlled trials (RCTs) that compared COVID-19 treatments in adult outpatients with confirmed SARS-CoV-2 infection were included.

Data extraction

One reviewer extracted data and assessed risk of bias and certainty of evidence (COE). A second reviewer verified data abstraction and assessments.

Data synthesis

The 26 included studies collected data before the emergence of the Omicron variant. Nirmatrelvir-ritonavir and casirivimab-imdevimab probably reduced hospitalizations (1% vs. 6% [1 RCT] and 1% vs. 4% [1 RCT], respectively; moderate COE). Nirmatrelvir-ritonavir probably reduced all-cause mortality (0% vs. 1% [1 RCT]; moderate COE), and regdanvimab probably improved recovery (87% vs. 72% [1 RCT]; moderate COE). Casirivimab-imdevimab reduced time to recovery by a median difference of 4 days (10 vs. 14 median days [1 RCT]; high COE). Molnupiravir may reduce all-cause mortality, sotrovimab may reduce hospitalization, and remdesivir may improve recovery (low COE). Lopinavir-ritonavir and azithromycin may have increased harms, and hydroxychloroquine may result in lower recovery rates (low COE). Other treatments had insufficient evidence or no statistical difference in efficacy and safety versus placebo.

Limitation

Many outcomes had few events and small samples.

Conclusion

Some antiviral medications and monoclonal antibodies may improve outcomes for outpatients with mild to moderate COVID-19. However, the generalizability of the findings to the currently dominant Omicron variant is limited.

Primary funding source

American College of Physicians. (PROSPERO: CRD42022323440).

SUBMITTER: Sommer I

PROVIDER: S-EPMC9709728 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.

Sommer Isolde I Dobrescu Andreea A Ledinger Dominic D Moser Isabel I Thaler Kylie K Persad Emma E Fangmeyer Martin M Emprechtinger Robert R Klerings Irma I Gartlehner Gerald G

Annals of internal medicine 20221129 1

<h4>Background</h4>Clinicians and patients want to know the benefits and harms of outpatient treatment options for SARS-CoV-2 infection.<h4>Purpose</h4>To assess the benefits and harms of 12 different COVID-19 treatments in the outpatient setting.<h4>Data sources</h4>Epistemonikos COVID-19 L·OVE Platform, searched on 4 April 2022.<h4>Study selection</h4>Two reviewers independently screened abstracts and full texts against a priori-defined criteria. Randomized controlled trials (RCTs) that compar ...[more]

PMID: 36442056

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Dataset Information

Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.

Background

Purpose

Data sources

Study selection

Data extraction

Data synthesis

Limitation

Conclusion

Primary funding source

Publications

Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.

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