Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.

ABSTRACT:

Background

Children ≤36 months with diffuse intrinsic pontine glioma (DIPG) have increased long-term survival (LTS, overall survival (OS) ≥24 months). Understanding distinguishing characteristics in this population is critical to improving outcomes.

Methods

Patients ≤36 months at diagnosis enrolled on the International DIPG Registry (IDIPGR) with central imaging confirmation were included. Presentation, clinical course, imaging, pathology and molecular findings were analyzed.

Results

Among 1183 patients in IDIPGR, 40 were eligible (median age: 29 months). Median OS was 15 months. Twelve patients (30%) were LTS, 3 (7.5%) very long-term survivors ≥5 years. Among 8 untreated patients, median OS was 2 months. Patients enrolled in the registry but excluded from our study b

SUBMITTER: Bartlett AL 

PROVIDER: S-EPMC9713498 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature