Dataset Information

Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial.

ABSTRACT:

Background

Cannabidiol (CBD), a major cannabinoid of Cannabis sativa, is widely consumed in prescription and non-prescription products. While CBD is generally considered 'non-intoxicating', its effects on safety-sensitive tasks are still under scrutiny.

Aim

We investigated the effects of CBD on driving performance.

Methods

Healthy adults (n = 17) completed four treatment sessions involving the oral administration of a placebo, or 15, 300 or 1500 mg CBD in a randomised, double-blind, crossover design. Simulated driving performance was assessed between ~45-75 and ~210-240 min post-treatment (Drives 1 and 2) using a two-part scenario with 'standard' and 'car following' (CF) components. The primary outcome was standard deviation of lateral position (SDLP), a well-established measure of vehicular control. Cognitive function, subjective experiences and plasma CBD concentrations were also measured. Non-inferiority analyses tested the hypothesis that CBD would not increase SDLP by more than a margin equivalent to a 0.05% blood alcohol concentration (Cohen's d_z = 0.50).

Results

Non-inferiority was established during the standard component of Drive 1 and CF component of Drive 2 on all CBD treatments and during the standard component of Drive 2 on the 15 and 1500 mg treatments (95% CIs < 0.5). The remaining comparisons to placebo were inconclusive (the 95% CIs included 0 and 0.50). No dose of CBD impaired cognition or induced feelings of intoxication (ps > 0.05). CBD was unexpectedly found to persist in plasma for prolonged periods of time (e.g. >4 weeks at 1500 mg).

Conclusion

Acute, oral CBD treatment does not appear to induce feelings of intoxication and is unlikely to impair cognitive function or driving performance (Registration: ACTRN12619001552178).

SUBMITTER: McCartney D

PROVIDER: S-EPMC9716488 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial.

McCartney Danielle D Suraev Anastasia S AS Doohan Peter T PT Irwin Christopher C Kevin Richard C RC Grunstein Ronald R RR Hoyos Camilla M CM McGregor Iain S IS

Journal of psychopharmacology (Oxford, England) 20220530 12

<h4>Background</h4>Cannabidiol (CBD), a major cannabinoid of <i>Cannabis sativa</i>, is widely consumed in prescription and non-prescription products. While CBD is generally considered 'non-intoxicating', its effects on safety-sensitive tasks are still under scrutiny.<h4>Aim</h4>We investigated the effects of CBD on driving performance.<h4>Methods</h4>Healthy adults (<i>n</i> = 17) completed four treatment sessions involving the oral administration of a placebo, or 15, 300 or 1500 mg CBD in a ra ...[more]

PMID: 35637624

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Dataset Information

Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial.

Background

Aim

Methods

Results

Conclusion

Publications

Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial.

Similar Datasets

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