Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer.

ABSTRACT: Theranostics - i.e., the combination of molecular imaging and radiopharmaceutical therapy of cancer targeting a common biological feature - is a rapidly expanding field owing the recent successes of novel radiopharmaceutical therapies, such as ¹⁷⁷Lu-based prostate-specific membrane antigen radioligand therapy of prostate cancer and peptide receptor radionuclide therapy of neuroendocrine tumours. Despite the ongoing technical developments in imaging-based dosimetry, the existence of tumour absorbed dose-efficacy and organ absorbed dose-toxicity relationships, as well as the high interpatient variability in absorbed doses per unit activity, radiopharmaceutical therapies are still mostly administered in a fixed-activity, one-size-fits-all fashion. This is at odds with the principle

SUBMITTER: Beauregard JM 

PROVIDER: S-EPMC9733022 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature