Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells.
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ABSTRACT:
SUBMITTER: Nikesjo F
PROVIDER: S-EPMC9748378 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells.
Nikesjö Frida F Sayyab Shumaila S Karlsson Lovisa L Apostolou Eirini E Rosén Anders A Hedman Kristofer K Lerm Maria M
Clinical epigenetics 20221214 1
Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. T ...[more]
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