Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma.

ABSTRACT: Studies to date have not resolved how diverse transcriptional programs contribute to the intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor associated with a dismal prognosis. Here, we identify distinct and commutable transcriptional states that confer discrete functional attributes in individual SCLC tumors. We combine an integrative approach comprising the transcriptomes of 52,975 single cells, high-resolution measurement of cell state dynamics at the single-cell level, and functional and correlative studies using treatment naïve xenografts with associated clinical outcomes. We show that individual SCLC tumors contain distinctive proportions of stable cellular states that are governed by bidirectional cell state transitions. Using drugs that target the ep

SUBMITTER: Gopal P 

PROVIDER: S-EPMC9750150 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature