Identification of Sex-Specific Genetic Variants Associated With Tau PET.

ABSTRACT:

Background and objectives

Important sex differences exist in tau pathology along the Alzheimer disease (AD) continuum, with women showing enhanced tau deposition compared with men, especially during the mild cognitive impairment (MCI) phase. This study aims to identify specific genetic variants associated with sex differences in regional tau aggregation, as measured with PET.

Methods

Four hundred ninety-three participants (women, n = 246; men, n = 247) who self-identified as White from the AD Neuroimaging Initiative study, with genotyping data and ¹⁸F-Flortaucipir tau PET data, were included irrespective of clinical diagnosis (cognitively normal [CN], MCI, and AD). We focused on the genetic variants within 10 genes previously shown to have sex-dependent effects on

SUBMITTER: Wang X 

PROVIDER: S-EPMC9756308 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature