Physiologic Effects of the Awake Prone Position Combined With High-Flow Nasal Oxygen on Gas Exchange and Work of Breathing in Patients With Severe COVID-19 Pneumonia: A Randomized Crossover Trial.

ABSTRACT: To determine the effect of the awake prone position (APP) on gas exchange and the work of breathing in spontaneously breathing patients with COVID-19-associated acute hypoxemic respiratory failure (AHRF) supported by high-flow nasal oxygen.

Design

Prospective randomized physiologic crossover multicenter trial.

Settings

Four ICUs in Marseille, France.

Patients

Seventeen patients with laboratory-confirmed COVID-19 pneumonia and Pao₂/Fio₂ less than or equal to 300 mm Hg while treated with high-flow nasal cannula oxygen therapy.

Interventions

Periods of APP and semirecumbent position (SRP) were randomly applied for 2 hours and separated by a 2-hour washout period.

Measurements and main results

Arterial blood gases, end-tidal CO₂

SUBMITTER: Lehingue S 

PROVIDER: S-EPMC9760623 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature