Swiss public health measures associated with reduced SARS-CoV-2 transmission using genome data.

ABSTRACT: Genome sequences from evolving infectious pathogens allow quantification of case introductions and local transmission dynamics. We sequenced 11,357 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from Switzerland in 2020-the sixth largest effort globally. Using a representative subset of these data, we estimated viral introductions to Switzerland and their persistence over the course of 2020. We contrasted these estimates with simple null models representing the absence of certain public health measures. We show that Switzerland's border closures decoupled case introductions from incidence in neighboring countries. Under a simple model, we estimate an 86 to 98% reduction in introductions during Switzerland's strictest border closures. Furthermore, the Swiss 2020 partia

SUBMITTER: Nadeau SA 

PROVIDER: S-EPMC9765449 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature