Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.

ABSTRACT:

Background and purpose

With an enlarging population of long-term oropharyngeal cancer survivors, dysphagia is an increasingly important toxicity following oropharynx cancer treatment. While lower doses to normal surrounding structures may be achieved with intensity modulated proton therapy (IMPT) compared to photon-based radiation, the clinical benefit is uncertain.

Methods and materials

Seventy-one patients with stage III/IV oropharyngeal cancer (AJCC 7th edition) undergoing definitive IMPT on a longitudinal prospective cohort study who had completed the MD Anderson Dysphagia Inventory (MDADI) at pre-specified time points were included.

Results

The majority of patients had HPV-positive tumors (85.9%) and received bilateral neck radiation (81.4%) with concurrent syste

SUBMITTER: Grant SR 

PROVIDER: S-EPMC9815953 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature