The effect of infant vitamin B₁₂ supplementation on neurodevelopment: a follow-up of a randomised placebo-controlled trial in Nepal.

ABSTRACT: The most critical period for brain development is before a child's second birthday. Standardised tests measuring neurodevelopment are more reliable when administered after this period. Severe vitamin B₁₂ deficiency affects brain development and function. In a randomised, double-blind, placebo-controlled trial in 600 Nepalese infants (6-11 months at enrolment), we found no effect of 2 µg vitamin B₁₂ daily for a year on neurodevelopment. The primary objective of the current study was to measure the effect of the intervention on the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) full scale intelligence quotient (FSIQ). We measured the effect on the Bayley Scales of Infant and Toddler Development 3rd edition at age 30-35 months (n 555). At age 42-4

SUBMITTER: Ulak M 

PROVIDER: S-EPMC9816651 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature