Exosome-Based Cell Homing and Angiogenic Differentiation for Dental Pulp Regeneration.

ABSTRACT: Exosomes have attracted attention due to their ability to promote intercellular communication leading to enhanced cell recruitment, lineage-specific differentiation, and tissue regeneration. The object of this study was to determine the effect of exosomes on cell homing and angiogenic differentiation for pulp regeneration. Exosomes (DPSC-Exos) were isolated from rabbit dental pulp stem cells cultured under a growth (Exo-G) or angiogenic differentiation (Exo-A) condition. The characterization of exosomes was confirmed by nanoparticle tracking analysis and an antibody array. DPSC-Exos significantly promoted cell proliferation and migration when treated with 5 × 10⁸/mL exosomes. In gene expression analysis, DPSC-Exos enhanced the expression of angiogenic markers including vascular

SUBMITTER: Ganesh V 

PROVIDER: S-EPMC9820194 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature