Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score.

ABSTRACT:

Background

Parkinson's disease (PD) is a highly age-related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across all common variants may be clinically useful for individual risk stratification. A polygenic hazard score methodology, leveraging a time-to-event framework, has recently been successfully applied in other age-related disorders.

Objectives

We aimed to develop and validate a polygenic hazard score model in sporadic PD.

Methods

Using a Cox regression framework, we modeled the polygenic hazard score in a training data set of 11,693 PD patients and 9841 controls. The score was then validated in an independent test data set of 5112 PD patients and 5372 controls and a sm

SUBMITTER: Pihlstrom L 

PROVIDER: S-EPMC9843635 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature