Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan.

ABSTRACT: Background: Left ventricular mass is a highly heritable disease. Previous studies have suggested common genetic variants to be associated with left ventricular mass; however, the roles of rare variants are still unknown. We performed targeted next-generation sequencing using the TruSight Cardio panel, which provides comprehensive coverage of 175 genes with known associations to 17 inherited cardiac conditions. Methods: We conducted next-generation sequencing using the Illumina TruSight Cardiomyopathy Target Genes platform using the 5% and 95% extreme values of left ventricular mass from community-based participants. After removing poor-quality next-generation sequencing subjects, including call rate <98% and Mendelian errors, 144 participants were used for the analysis. We pe

SUBMITTER: Fan HY 

PROVIDER: S-EPMC9879005 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature