Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses.

ABSTRACT:

Background

The liver is responsible for a range of functions in vertebrates, such as metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between the parasite and host. Although malarial hepatitis is a common clinical complication of severe malaria, other malaria-related liver changes have been overlooked during the blood stage of the parasite life-cycle, in contrast to the many studies that have focused on parasite invasion of and replication in the liver during the hepatic stage of the parasite.

Methods

A rodent model of malaria was established using Plasmodium yoelii strain 17XL, a lethal strain of rodent malaria, for liver transcriptomic profiling.

Results

Differentially expressed messenger RNAs were associated with innate and ada

SUBMITTER: Hu X 

PROVIDER: S-EPMC9885691 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature