Heteromerization between α_2A adrenoceptors and different polymorphic variants of the dopamine D₄ receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.

ABSTRACT: Polymorphic alleles of the human dopamine D₄ receptor gene (DRD4) have been consistently associated with individual differences in personality traits and neuropsychiatric disorders, particularly between the gene encoding dopamine D_4.7 receptor variant and attention deficit hyperactivity disorder (ADHD). The α_2A adrenoceptor gene has also been associated with ADHD. In fact, drugs targeting the α_2A adrenoceptor (α_2AR), such as guanfacine, are commonly used in ADHD treatment. In view of the involvement of dopamine D₄ receptor (D₄R) and α_2AR in ADHD and impulsivity, their concurrent localization in cortical pyramidal neurons and the demonstrated ability of D₄R to form functional heteromers with o

SUBMITTER: Casado-Anguera V 

PROVIDER: S-EPMC9885860 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature