Methylotrophic bacteria with cobalamin-dependent mutases in primary metabolism as potential strains for vitamin B₁₂ production.

ABSTRACT: Several bacterial species are known for their ability to synthesize vitamin B₁₂ but biotechnological vitamin B₁₂ production today is restricted to Pseudomonas denitrificans and Propionibacterium freudenreichii. Nevertheless, the rising popularity of veganism leads to a growing demand for vitamin B₁₂ and thereby interest in alternative strains which can be used as efficient vitamin B₁₂ sources. In this work, we demonstrate that methylotrophic microorganisms which utilize the ethylmalonyl-CoA pathway containing B₁₂-dependent enzymes are capable of active vitamin B₁₂ production. Several bacteria with an essential function of the pathway were tested for vitamin B₁₂ synthesis. Among the identified strains, Hyphomicrobi

SUBMITTER: Dudko D 

PROVIDER: S-EPMC9925536 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature