Characterization of a Conjugative Hybrid Plasmid Coharboring bla_KPC-2 and bla_IMP-4 in a Klebsiella quasipneumoniae Clinical Isolate.

ABSTRACT: Generation of hybrid MDR plasmids accelerated the evolution and transmission of resistance genes. In this study, we characterized a bla_KPC-2- and bla_IMP-4-coharboring conjugative hybrid plasmid constituted of an IncHI5 plasmid-like region, an IncFII(Yp)/IncFIA plasmid-like region, and a KPN1344 chromosome-like region from a clinical ST852-KL18 Klebsiella quasipneumoniae strain. The bla_IMP-4 gene was captured by a novel integron In1965, and the bla_KPC-2 gene was located on a new non-Tn4401 group I NTE_KPC element. Both bla_KPC-2- and bla_IMP-4-containing genetic architectures were distinguished from classical structures, highlighting the constant evolution of the

SUBMITTER: Dong H 

PROVIDER: S-EPMC9927271 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature