Coexistence of bla_IMP-4 and bla_SFO-1 in an IncHI5B plasmid harbored by tigecycline-non-susceptible Klebsiella variicola strain.

ABSTRACT:

Background

Klebsiella variicola is considered a newly emerging human pathogen. Clinical isolates of carbapenemase and broad-spectrum β-lactamase-producing K. variicola remain relatively uncommon. A strain of K. variicola 4253 was isolated from a clinical sample, and was identified to carry the bla_IMP-4 and bla_SFO-1 genes. This study aims to discern its antibiotic resistance phenotype and genomic characteristics.

Methods

Species identification was conducted using MALDI-TOF/MS. PCR identification confirmed the presence of the bla_IMP-4 and bla_SFO-1 genes. Antibiotic resistance phenotype and genomic characteristics were detected by antimicrobial susceptibility testing and whole-genome sequencing. Plasmid characterization was carried ou

SUBMITTER: Chen H 

PROVIDER: S-EPMC10918965 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature