Circulating LncRNAs landscape as potential biomarkers in breast cancer.

ABSTRACT: In Iran, the delay in diagnosis and treatment of breast cancer results in low survival rates. It is essential to characterize new therapeutic targets and prognostic breast cancer biomarkers. The rising evidence suggested that long non-coding RNAs (lncRNAs) expression levels are deregulated in human cancers and can use as biomarkers for the rapid diagnosis of breast cancer. In the present study, a quantitative real-time polymerase chain reaction (qRT-PCR) technique was used to measure 20 oncogenic and tumor suppressor lncRNAs expression levels in whole blood samples of female breast cancer patients and healthy women. Receiver operating characteristic curve (ROC) was used to assess the diagnostic value of each selected lncRNA as a biomarker. The results revealed that some circulating lncRNAs

SUBMITTER: Pourramezan Z 

PROVIDER: S-EPMC9940007 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature