Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis.

ABSTRACT:

Background

The imaging g-ratio, estimated from axonal volume fraction (AVF) and myelin volume fraction (MVF), is a novel biomarker of microstructural tissue integrity in multiple sclerosis (MS).

Objective

To assess axonal and myelin changes and their inter-relationship as measured by g-ratio in the optic radiations (OR) in people with MS (pwMS) with and without previous optic neuritis (ON) compared to healthy controls (HC).

Methods

Thirty pwMS and 17 HCs were scanned on a 3Tesla Connectom scanner. AVF and MVF, derived from a multi-shell diffusion protocol and macromolecular tissue volume, respectively, were measured in normal-appearing white matter (NAWM) and lesions within the OR and used to calculate imaging g-ratio.

Results

OR AVF and MVF were decreased in p

SUBMITTER: Krijnen EA 

PROVIDER: S-EPMC9940187 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature