Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC9945867 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Li Haoting H Mattingly Anne E AE Smith Richard D RD Melander Roberta J RJ Ernst Robert K RK Melander Christian C
RSC medicinal chemistry 20221201 2
Multidrug resistant (MDR) bacterial infections have become increasingly common, leading clinicians to rely on last-resort antibiotics such as colistin. However, the utility of colistin is becoming increasingly compromised as a result of increasing polymyxin resistance. Recently we discovered that derivatives of the eukaryotic kinase inhibitor meridianin D abrogate colistin resistance in several Gram-negative species. A subsequent screen of three commercial kinase inhibitor libraries led to the i ...[more]