Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson's Disease?

ABSTRACT:

Background

Parkinson's disease (PD) is characterized by a progressive loss of nigrostriatal dopaminergic neurons with impaired motor and non-motor symptoms. It has been suggested that motor asymmetry could be caused due to an imbalance in dopamine levels, as visualized by dopamine transporter single emission computed tomography test (DAT-SPECT), which might be related to indirect measures of neurodegeneration, evaluated by the Montreal Cognitive Assessment (MOCA) and α-synuclein levels in the cerebrospinal fluid (CSF). Therefore, this study aimed to understand the correlation between disease laterality, DAT-SPECT, cognition, and α-synuclein levels in PD.

Methods

A total of 28 patients in the moderate-advanced stage of PD were subjected to neurological evaluation, TRODAT-1-SP

SUBMITTER: Coutinho AM 

PROVIDER: S-EPMC9952987 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature