Breast Cancer Risk Assessment Tools for Stratifying Women into Risk Groups: A Systematic Review.

ABSTRACT:

Background

The benefits and harms of breast screening may be better balanced through a risk-stratified approach. We conducted a systematic review assessing the accuracy of questionnaire-based risk assessment tools for this purpose.

Methods

Population: asymptomatic women aged ≥40 years; Intervention: questionnaire-based risk assessment tool (incorporating breast density and polygenic risk where available); Comparison: different tool applied to the same population; Primary outcome: breast cancer incidence; Scope: external validation studies identified from databases including Medline and Embase (period 1 January 2008-20 July 2021). We assessed calibration (goodness-of-fit) between expected and observed cancers and compared observed cancer rates by risk group. Risk of bias was

SUBMITTER: Velentzis LS 

PROVIDER: S-EPMC9953796 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature