Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC9958358 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection.
Liu Yaming Y Wu Yangtao Y Jiang Xiaoming X Chen Bo B Lu Jing J Cai Zexin Z Fu Baorong B Zheng Wei W Wu Ruihong R Chen Gang G Tian Shulan S Ren Jianlin J
iScience 20230201 3
Apolipoprotein H (APOH) is involved in lipid metabolism and functions as an acute-phase protein during hepatitis B virus (HBV) infection. Herein, we explored whether APOH acts on the development of fatty liver upon chronic HBV infection. Serum APOH level was significantly lower in cirrhosis patients than in healthy controls or patients with chronic infection. It showed sex bias, with elevated levels in female patients with chronic infection. Also, serum APOH levels were negatively correlated wit ...[more]
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