Expanding the Disease Network of Glioblastoma Multiforme via Topological Analysis.
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ABSTRACT:
SUBMITTER: Badkas A
PROVIDER: S-EPMC9965660 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Expanding the Disease Network of Glioblastoma Multiforme via Topological Analysis.
Badkas Apurva A De Landtsheer Sébastien S Sauter Thomas T
International journal of molecular sciences 20230204 4
Glioblastoma multiforme (GBM), a grade IV glioma, is a challenging disease for patients and clinicians, with an extremely poor prognosis. These tumours manifest a high molecular heterogeneity, with limited therapeutic options for patients. Since GBM is a rare disease, sufficient statistically strong evidence is often not available to explore the roles of lesser-known GBM proteins. We present a network-based approach using centrality measures to explore some key, topologically strategic proteins ...[more]
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