Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.

ABSTRACT:

Research question

Adenomyosis is a common uterine disorder of uncertain causes. Can transcriptomic analyses of the endometrium and myometrium reveal potential mechanisms underlying adenomyosis pathogenesis?

Design

Transcriptomic profiles of eutopic endometrium and myometrium from women with and without diffuse adenomyosis and with symptomatic FIGO type 2-5 fibroids in the proliferative phase of the menstrual cycle were assessed using RNA sequencing and bioinformatic analysis. Differentially expressed genes (DEG) and potential pathways were validated by quantitative reverse transcription polymerase chain reaction, immunoblotting and Masson staining, using additional clinical samples.

Results

Top biological processes in the endometrium of women with versus without adeno

SUBMITTER: Zhai J 

PROVIDER: S-EPMC9976941 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature