Methacholine Challenge Testing: Comparison of FEV₁ and Airway Resistance Parameters.

ABSTRACT:

Background

A 20% reduction in the FEV₁ is routinely used as an end point for methacholine challenge testing (MCT). Measurement of FEV₁ is effort dependent, and some patients are not able to perform acceptable and repeatable forced expiration maneuvers. The goal of the present study was to investigate the diagnostic value of airway resistance measurement by forced oscillation technique (FOT), body plethysmography, and interrupter technique compared with the traditionally accepted standard FEV₁ measurement in evaluating the responsiveness to methacholine during MCT.

Methods

We included in the study adult subjects referred for MCT because of asthma-like symptoms and with normal baseline spirometry. We modified routine MCT protocol by adding the

SUBMITTER: Urbankowski T 

PROVIDER: S-EPMC9994076 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature