Dataset Information
VanEunen2012 - Yeast Glycolysis (glucose upshift)
Ontology highlight
ABSTRACT: This is corresponding to the model of yeast glycolysis "glucose upshift" condition described in the paper "Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics" by van Eunen et al published in Plos Comput Biol, 2012.
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Shodhan Rao
PROVIDER: MODEL1403250001 | biostudies-other |
SECONDARY ACCESSION(S): 22570597
REPOSITORIES: biostudies-other
Publications
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
PLoS computational biology 20120426 4
A decade ago, a team of biochemists including two of us, modeled yeast glycolysis and showed that one of the most studied biochemical pathways could not be quite understood in terms of the kinetic properties of the constituent enzymes as measured in cell extract. Moreover, when the same model was later applied to different experimental steady-state conditions, it often exhibited unrestrained metabolite accumulation.Here we resolve this issue by showing that the results of such ab initio modeling ...[more]
