Dataset Information
Trares2022 - Crosstalk between the canonical and non-canonical NF-kB pathways, Petri net
Ontology highlight
ABSTRACT:
SUBMITTER: Ann-Kathrin Otto
PROVIDER: MODEL2207210003 | biostudies-other |
SECONDARY ACCESSION(S): 34688841
REPOSITORIES: biostudies-other
Publications
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase.
Immunity 20041001 4
The NF-kappaB-inducing kinase (NIK) induces proteolytic processing of NF-kappaB2/p100 and, hence, the generation of NF-kappaB dimers such as p52:RelB but was suggested not to signal for the processing of IkappaB. Here, we show that although the induction of IkappaB degradation in lymphocytes by TNF is independent of NIK, its induction by CD70, CD40 ligand, and BLyS/BAFF, which all also induce NF-kappaB2/p100 processing, does depend on NIK function. Both CD70 and TNF induce recruitment of the IKK ...[more]
