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Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactions

ABSTRACT: Significance Statement: Human neutrophil-endothelial interactions biosynthesize a potent pro-resolving molecule from omega-3 DHA via transcellular metabolism, that is also produced by human macrophages solo and mononuclear cells. The proposed bioactive elucidated structure is 4S,13R-dihydroxy-5E,7Z,10Z,14E,16Z,19Z-docosahexaenoic acid, which functions to limit neutrophil infiltration in vivo, reduce neutrophil adherence to endothelial cells, prevent endothelial senescence, as well as counter-regulate proinflammatory cytokines and eicosanoids, and activates human macrophage efferocytosis.

ORGANISM(S): Homo sapiens (human) Mus musculus (mouse)

SUBMITTER: Robert Nshimiyimana 

PROVIDER: S-BSST2628 | biostudies-other |

REPOSITORIES: biostudies-other

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