Transcription profiling by array of human breast cancers after treatment with tamoxifen

ABSTRACT: Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)-positive subtypes has been inconsistent. Refinement of their molecular definition is therefore needed. Materials and methods: We have previously reported a gene-expression grade index (GGI) which defines histological grade based on gene expression profiles. Using this algorithm, we assigned ER-positive BC to either high or low genomic grade subgroups and compared these to previously reported ER-positive molecular classifications. As further validation,

ORGANISM(S): Homo sapiens

SUBMITTER: Loi S 

PROVIDER: S-ECPF-GEOD-6532 | biostudies-other | 2007 Apr

REPOSITORIES: biostudies-other