Ontology highlight
ABSTRACT:
SUBMITTER: Chen RX
PROVIDER: S-EPMC6795808 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Chen Ri-Xin RX Chen Xin X Xia Liang-Ping LP Zhang Jia-Xing JX Pan Zhi-Zhong ZZ Ma Xiao-Dan XD Han Kai K Chen Jie-Wei JW Judde Jean-Gabrie JG Deas Olivier O Wang Feng F Ma Ning-Fang NF Guan Xinyuan X Yun Jing-Ping JP Wang Feng-Wei FW Xu Rui-Hua RH Dan Xie
Nature communications 20191016 1
Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metastasis (LM) and predicts poorer patient survival. The upregulated expression of circNSUN2 promotes LM in PDX metastasis models in vivo and accelerates cancer cells invasion in vitro. ...[more]