Developmental mitochondrial Complex I activity determines lifespan

ABSTRACT: Aberrant mitochondrial function has been linked to a growing number of human diseases. Observations from in vivo models with altered mitochondrial function suggest that maladaptations to mitochondrial dysfunction may underlie disease pathology. We hypothesised that the severity of this maladaptation is influenced by the organism's plasticity when mitochondrial dysfunction occurs. To investigate this, we utilised inducible fly models of mitochondrial complex I (CI) dysfunction to impair mitochondrial function from early development or after eclosion. Here, we demonstrate that early-life (developmental) mitochondrial dysfunction leads to marked reductions in survival and stress resistance in adulthood, whereas flies with CI dysfunction initiated in adulthood are long-lived and stress-resista

SUBMITTER: Rhoda Stefanatos 

PROVIDER: S-SCDT-10_1038-S44319-025-00416-6 | biostudies-other |

REPOSITORIES: biostudies-other