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Randomized controlled, three-arm parallel group, clinical trial on efficacy and safety of rhythmic embrocations on post-surgical stress in colorectal cancer patients

ABSTRACT: Interventions: Group 1: Rhythmical Embrocations (RE) performed by experts: Every RE will be performed using pure almond oil (approx. 2 mL per treatment) in the morning (between 8 and 10 pm) and the evening (between 6 and 10pm) for approx. 10 minutes. Regarding intensity of the massage the treatment of the back will use intensities between 1-3 and the treatment of the back will use intensities between 1-5 (on a scale of 1=softest massage possible” and 10=very intense massage”). The patients are asked to rest for 20 minutes after the embrocation. Staff and patients in the same room will be informed about the intervention and resting time orally and by a sign at the patient’s door signaling ‘study intervention, please do not disturb until x:xx’ and will be asked not to interrupt during these periods. 1. RE of the back in the morning: The patient is sitting at the bedside and leaning with his arms on a nightstand or over a pillow; safe sitting has to be achieved in this position as an obligatory prerequisite for this treatment. During this treatment, only one hand is touching the patient at one time. The treatment can be described as two different movements: in the first movement the hand is moved in circles over one side of the back with the circles going down; the circles are clockwise at the left side of the back and anti-clockwise at the right side of the back; there is a slightly stronger touch when going down above the M. erector spinae to the middle of back (the spine is not touched within these movements); the second movement is a line on one side of the back and then the other going down. Every movement is repeated about 3 times on every side of the back. 2. RE of the feet in the evening: The patient is lying in his bed with a knee roll under his knees (or something simi Primary outcome(s): Stress as measured with heart rate variability (SDNN) on day 6 (after last treatment) Study Design: Allocation: Randomized controlled study; Masking: Open (masking not used); Control: active; Assignment: parallel; Study design purpose: supportive care

DISEASE(S): Malignant Neoplasm Of Rectum,Malignant Neoplasm Of Rectosigmoid Junction,Malignant Neoplasm Of Colon

PROVIDER: 2438044 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Massage therapy is commonly used for the physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. While there is some evidence that massage may relieve pain in injured muscle, the cellular effects remain unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of eleven young, male participants after exercised-induced muscle damage. Muscle biopsies were acquired from the quadriceps (vastus lateralis) at baseline (rest), immediately after 10 minutes of massage treatment (0h), and after a 2.5 hour period of recovery. We found that massage activated the mechanotransduction signaling pathways FAK and Erk1/2, potentiated mitochondrial biogenesis signaling (nuclear PGC-1α), and mitigated the rise in NFkB (p65) nuclear accumulation caused by muscle trauma. Moreover, in spite of having no effect on muscle metabolites (glycogen, lactate), massage attenuated the production of the inflammatory cytokines TNF-α and IL-6 and reduced HSP27 phosphorylation, effectively mitigating cellular stress resulting from myofiber injury. In summary, massage therapy appears to be clinically beneficial when administered to acutely damaged skeletal muscle by reducing inflammation and promoting mitochondrial biogenesis. 55 muscle biopsies were used in this study as material to evaluate the effects of massage on gene expression. These biopsies were taken from the vastus lateralis of eleven healthy recreationally active males with full ethical approval at McMaster's university. Each individual had an initial biopsy at rest (baseline), followed by exercist testing for peak aerobic capacity. On a second visit, the individual performed a bout of exhaustive aerobic exercise, prior to recieving a randomized massage treatment to one leg. Immediatley following the exercise, subjects were allowed to recover for 10 minutes, while massage oil was lightly applied to both quadriceps. Then a single leg was randomized to recieve massage treatment for 10 minutes. Subjects then rested for 10 minutes, and one additional biopsies were carried out (on each leg). Two and half hours later (3 hours after the cessation of the exercise bout), 2 more biopsies were taken (one from each leg). This amounted to 5 biopsies from each individual.

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Randomized controlled, three-arm parallel group, clinical trial on efficacy and safety of rhythmic embrocations on post-surgical stress in colorectal cancer patients

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