Neutrophils Escort Circulating Tumor Cells to Enable Cell Cycle Progression

ABSTRACT: Circulating tumor cells (CTCs) are precursors of metastasis in several cancer types, and are occasionally found within the bloodstream in association with non-malignant cells such as white blood cells (WBCs). The identity and function of these CTC-associated WBCs, as well as the molecular features that define the interaction between WBCs and CTCs are unknown. Here, we achieve the isolation and interrogation of individual CTC-associated WBCs, alongside with corresponding cancer cells within each CTC-WBC-cluster, from multiple breast cancer patients and mouse models.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE109761 | GEO | 2019/02/06

REPOSITORIES: GEO