Dataset Information


Genome-wide occupancy of LSD1 in differentiating and differentiated C2C12 myoblasts.

ABSTRACT: ChIP-seq analysis of LSD1 in C2C12 cells. We found that LSD1 directly regulates the expression of fiber and metabolism genes during myogenesis. Results provide insight into the metabolic prgramming mechanisms of myogenesis. Overall design: Examination of LSD1/DNA interaction in C2C12 myoblasts 48 h (day 2) and 120 h (day 5) post-differentiation.

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: Kotaro Anan  

PROVIDER: GSE109846 | GEO | 2018-03-19


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The metabolic properties of cells are formed under the influence of environmental factors such as nutrients and hormones. Although such a metabolic program is likely initiated through epigenetic mechanisms, the direct links between metabolic cues and activities of chromatin modifiers remain largely unknown. In this study, we show that lysine-specific demethylase-1 (LSD1) controls the metabolic program in myogenic differentiation, under the action of catabolic hormone, glucocorticoids. By using t  ...[more]

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