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Expression Profile of Genes in Trabecular Meshwork Cells Treated with Dexamethasone

ABSTRACT: Treatment with glucocorticoids is known to cause ocular hypertension in humans which can lead to steriod-induced glaucoma We used microarrays to determine changes in gene expression in two human trabecular meshwork (TM) cell isolates (TM-4 and TM-2) from the same donor that could explain the increase in ocular hypertension.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124114 | GEO | 2018/12/20

REPOSITORIES: GEO

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Dexamethasone induced gene expression changes in the human trabecular meshwork

Project description:One of the undesirable side effects of glucocorticoid use is the potential development of elevated intraocular pressure and glaucoma. The precise mechanisms through which steroid use induces ocular hypertension are unclear. The purpose of this study was to identify gene expression changes induced by steroids in the human trabecular meshwork and the underlying sclerocorneal tissue.

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Dexamethasone induced gene expression changes in the human trabecular meshwork

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Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

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