MRNA expression changes in CCM3-deficient endothelial cells

ABSTRACT: Loss-of-function variants in CCM3/PDCD10 predispose to cerebral cavernous malformations (CCMs) that are vascular lesion of the central nervous system. Using CRISPR/Cas9 genome editing and RNA sequencing, we have shown that long-term inactivation of CCM3 in human endothelial cells dysregulates fibronectin expression and thus impairs the assembly of a functional fibronectin matrix by endothelial cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137425 | GEO | 2020/07/06

REPOSITORIES: GEO