Genomics

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Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infection


ABSTRACT: The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected transgenic mice overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) with Mycobacterium tuberculosis by aerosol and found increased bacterial loads in the lungs of macIL-10tg mice. To identify programs of genes regulated by IL-10 and associated with increased mycobacterial replication, genome-wide expression analysis was performed. Keywords: Effect of infection; effect of genotype; timecourse

ORGANISM(S): Mus musculus

PROVIDER: GSE14316 | GEO | 2009/01/08

SECONDARY ACCESSION(S): PRJNA111319

REPOSITORIES: GEO

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