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Comparative transcriptional analysis of the satellite glial cell injury response

ABSTRACT: The recent advance in single cell RNAseq technologies has enabled a new approach to investigate satellite glial cells (SGCs). Here we publish a dataset from mice subjected to sciatic nerve injury as well as a dataset from dorsal root ganglia cells after 3 days in culture. We use a meta-analysis approach to compare the injury response with that in other published datasets and conclude that SGCs share a common signature following sciatic nerve crush and sciatic ligation, involving transcriptional regulation of cholesterol biosynthesis. We also observed a considerable transcriptional change when culturing SGCs, suggesting that some differentiate into a specialised in vitro state, while others start resembling Schwann cell-like precursors.

ORGANISM(S): Mus musculus

PROVIDER: GSE188971 | GEO | 2021/11/23

REPOSITORIES: GEO

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The transcriptional fingerprint of satellite glial cells changes over time following peripheral nerve injury

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