Genomics

Dataset Information

0

Nasally-delivered interferon-λ in mice protects against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron


ABSTRACT: The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had devastating impacts on our global society. Although vaccines and monoclonal antibody countermeasures have reduced the morbidity and mortality associated with SARS-CoV-2 infection, variants with constellations of mutations in the spike gene threaten their efficacy. Therefore, antiviral interventions that are resistant to further virus evolution may be needed. Here, we show IFN-λ protects against SARS-CoV-2 B.1.351 (Beta) and B.1.1529 (Omicron) variants in three strains of conventional and human ACE2 transgenic mice. Prophylaxis or therapy with nasally-delivered IFN-λ2 limited infection of historical or variant (B.1.351 and B.1.1.529) SARS-CoV-2 strains in both the upper and lower respiratory tracts without causing excessive inflammation. In the lung, IFN-λ was produced preferentially in epithelial cells and acted on radio-resistant cells to protect against of SARS-CoV-2 infection. Thus, inhaled IFN-λ may have promise as a treatment for evolving SARS-CoV-2 variants that develop resistance to antibody-based countermeasures.

ORGANISM(S): Mus musculus

PROVIDER: GSE193990 | GEO | 2022/02/08

REPOSITORIES: GEO

Similar Datasets

2022-01-11 | GSE174635 | GEO
2022-10-14 | GSE215814 | GEO
2023-09-22 | E-MTAB-13308 | biostudies-arrayexpress
2010-12-01 | E-GEOD-22581 | biostudies-arrayexpress
2022-04-05 | GSE199743 | GEO
2010-02-24 | E-GEOD-17400 | biostudies-arrayexpress
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
2020-10-20 | PXD021685 | Pride
2021-10-23 | GSE186360 | GEO
2023-05-28 | GSE228112 | GEO