Genomics

Dataset Information

28

PU.1 in normal erythroid progenitors and erythroleukemia cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Sandeep Nagaraj Wontakal 

PROVIDER: GSE21953 | GEO | 2011-06-23

SECONDARY ACCESSION(S): GSE21949 GSE21950PRJNA127243

REPOSITORIES: GEO

altmetric image

Publications

A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.

Wontakal Sandeep N SN   Guo Xingyi X   Will Britta B   Shi Minyi M   Raha Debasish D   Mahajan Milind C MC   Weissman Sherman S   Snyder Michael M   Steidl Ulrich U   Zheng Deyou D   Skoultchi Arthur I AI  

PLoS genetics 20110609 6


PU.1 is a hematopoietic transcription factor that is required for the development of myeloid and B cells. PU.1 is also expressed in erythroid progenitors, where it blocks erythroid differentiation by binding to and inhibiting the main erythroid promoting factor, GATA-1. However, other mechanisms by which PU.1 affects the fate of erythroid progenitors have not been thoroughly explored. Here, we used ChIP-Seq analysis for PU.1 and gene expression profiling in erythroid cells to show that PU.1 regu  ...[more]

Similar Datasets

2013-06-14 | E-GEOD-46216 | ArrayExpress
2015-06-08 | E-GEOD-63837 | ArrayExpress
2012-02-27 | GSE35385 | GEO
2013-06-27 | E-GEOD-48345 | ArrayExpress
2012-11-22 | E-GEOD-42441 | ArrayExpress
2011-06-23 | E-GEOD-21950 | ArrayExpress
| GSE87316 | GEO
2014-05-01 | E-GEOD-45451 | ArrayExpress
2013-01-28 | E-GEOD-43626 | ArrayExpress
2014-09-25 | E-GEOD-61426 | ArrayExpress