Dataset Information


PU.1 in normal erythroid progenitors and erythroleukemia cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Sandeep Nagaraj Wontakal 

PROVIDER: GSE21953 | GEO | 2011-06-23



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A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.

Wontakal Sandeep N SN   Guo Xingyi X   Will Britta B   Shi Minyi M   Raha Debasish D   Mahajan Milind C MC   Weissman Sherman S   Snyder Michael M   Steidl Ulrich U   Zheng Deyou D   Skoultchi Arthur I AI  

PLoS genetics 20110609 6

PU.1 is a hematopoietic transcription factor that is required for the development of myeloid and B cells. PU.1 is also expressed in erythroid progenitors, where it blocks erythroid differentiation by binding to and inhibiting the main erythroid promoting factor, GATA-1. However, other mechanisms by which PU.1 affects the fate of erythroid progenitors have not been thoroughly explored. Here, we used ChIP-Seq analysis for PU.1 and gene expression profiling in erythroid cells to show that PU.1 regu  ...[more]

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