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Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing.

ABSTRACT: In this project we investigate the role of RNA binding protein PTBP1 in cardiac fibrosis through the conditional deletion of PTBP1 in mouse cardiac fibroblasts. We isolated cardiac fibroblasts from Ptbp1fl/fl mice, deleted PTBP1 with Adenoviral-Cre, and stimulated cardiac fibroblasts with TGFb to perform deep RNA sequencing studies on the cardiac fibroblast to myofibroblast transformation.

ORGANISM(S): Mus musculus

PROVIDER: GSE287133 | GEO | 2026/06/01

REPOSITORIES: GEO

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Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing.

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